Satya P Kalra Selected Research

Leptin

1/2016	Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets.
12/2015	Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss.
10/2013	Should leptin replace insulin as a lifetime monotherapy for diabetes type 1 and 2?
7/2011	Hypothalamic leptin gene therapy prevents weight gain without long-term detrimental effects on bone in growing and skeletally mature female rats.
1/2010	Neuroendocrine control of energy homeostasis: update on new insights.
10/2009	Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation.
5/2009	Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice.
9/2008	Disruption in the leptin-NPY link underlies the pandemic of diabetes and metabolic syndrome: new therapeutic approaches.
4/2008	Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice.
1/2008	Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions.

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Satya P Kalra Research Topics

Disease

19	Obesity 01/2016 - 05/2002
11	Weight Gain 07/2011 - 05/2002
9	Body Weight (Weight, Body) 12/2015 - 05/2002
8	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2010 - 11/2002
7	Hyperinsulinism (Hyperinsulinemia) 10/2009 - 06/2002
6	Hyperglycemia 10/2013 - 01/2006
4	AIDS-Related Complex (ARC) 12/2005 - 12/2002
3	Insulin Resistance 10/2009 - 01/2006
3	Hyperphagia (Overeating) 05/2009 - 04/2003
2	Weight Loss (Weight Reduction) 12/2015 - 07/2005
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 10/2013 - 10/2009
2	Diabetes Mellitus 10/2009 - 04/2008
2	Type 2 Diabetes Mellitus (MODY) 12/2006 - 09/2006
2	Hypersensitivity (Allergy) 09/2006 - 09/2006
1	Osteoporosis 12/2015
1	Lipodystrophy 10/2013
1	Inflammation (Inflammations) 04/2008
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2008
1	Metabolic Diseases (Metabolic Disease) 01/2006
1	Dyslipidemias (Dyslipidemia) 01/2006
1	Hypothalamic Diseases 10/2005
1	Infertility (Sterility) 06/2004
1	Seizures (Absence Seizure) 01/2003
1	Failure to Thrive 12/2002
1	Prader-Willi Syndrome (Syndrome, Prader-Willi) 12/2002

Drug/Important Bio-Agent (IBA)

34	LeptinIBA 01/2016 - 05/2002
11	Insulin (Novolin)FDA Link 10/2013 - 05/2002
9	GhrelinIBA 12/2005 - 06/2002
5	Glucose (Dextrose)FDA LinkGeneric 10/2013 - 05/2002
4	Neuropeptide YIBA 09/2008 - 01/2003
4	Peptides (Polypeptides)IBA 08/2005 - 12/2002
3	Messenger RNA (mRNA)IBA 12/2005 - 05/2002
3	Nonesterified Fatty Acids (NEFA)IBA 09/2004 - 05/2002
2	Biomarkers (Surrogate Marker)IBA 12/2015 - 04/2008
2	Blood Glucose (Blood Sugar)IBA 10/2013 - 05/2009
2	AdipokinesIBA 02/2007 - 08/2006
2	MelanocortinsIBA 09/2006 - 12/2002
2	AdiponectinIBA 08/2006 - 09/2004
2	Hormones (Hormone)IBA 01/2006 - 12/2005
2	Gonadotropin-Releasing Hormone (GnRH)FDA Link 12/2005 - 07/2004
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 07/2004 - 12/2002
2	NeuropeptidesIBA 01/2003 - 12/2002
1	OsteocalcinIBA 12/2015
1	Therapeutic UsesIBA 05/2009
1	Dietary Fats (Dietary Fat)IBA 04/2008
1	Interleukin-6 (Interleukin 6)IBA 04/2008
1	salicylhydroxamic acid (SHAM)IBA 09/2006
1	Melanocortin Receptors (Melanocortin Receptor)IBA 09/2006
1	Insulin-Like PeptidesIBA 07/2005
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2004
1	Progesterone FDA LinkGeneric 07/2004
1	Green Fluorescent ProteinsIBA 12/2003
1	GalaninIBA 10/2003
1	Butyric Acid (Butanoic Acid)IBA 10/2003
1	CatecholaminesIBA 10/2003
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2003
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2003
1	alpha-MSHIBA 12/2002
1	Triglycerides (Triacylglycerol)IBA 11/2002
1	Leukemia Inhibitory FactorIBA 05/2002

Therapy/Procedure

7	Therapeutics 05/2009 - 05/2002
1	Injections 10/2013
1	Ovariectomy (Oophorectomy) 08/2006